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Either way, the idea is usually: Can you keep just enough medication in your system to maintain the benefit without taking the full dose indefinitely
That being said, different mechanisms may offer different side effect profiles, and its possible that future multi-agonists could yield improved tolerability profiles
Antidromic axon reflexes may then cause further release of CGRP in the dura (30)
Hormonal balance
In addition to its function in regulating metabolism, GLP-1 signaling has a notable impact on anti-inflammatory mechanisms and cytoprotection in the gut
Pillai et al., 2014
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